Dr. MacDonald speaks in the University of Pittsburgh Senior Vice Chancellor Seminar Series
Synaptic Protein Network Impairments in Schizophrenia
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Recent News
Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia published in JAMA Psychiatry
Are protein levels altered within synapses from the primary auditory cortex of individuals with schizophrenia and, if so, are these differences restricted to the synapse or present throughout the gray matter?
Laser capture microdissection–targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex
Here, we developed and validated a laser capture microdissection–mass spectrometry (LCM-MS) approach to quantify over 200 proteins in cortical layers 3 and 5 of two cohorts of human subjects as well as a monkey model of postmortem interval.