Dr. MacDonald speaks in the University of Pittsburgh Senior Vice Chancellor Seminar Series
Synaptic Protein Network Impairments in Schizophrenia
Synaptic Protein Network Impairments in Schizophrenia
Are protein levels altered within synapses from the primary auditory cortex of individuals with schizophrenia and, if so, are these differences restricted to the synapse or present throughout the gray matter?
Here, we developed and validated a laser capture microdissection–mass spectrometry (LCM-MS) approach to quantify over 200 proteins in cortical layers 3 and 5 of two cohorts of human subjects as well as a monkey model of postmortem interval.