Grubisha MJ, Sweet RA, MacDonald ML. Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research. Front Mol Neurosci. 2021 Jul 16;14:689495. doi: 10.3389/fnmol.2021.689495. PMID: 34335181; PMCID: PMC8322442.
Read The paperDumrongprechachan V, Salisbury RB, Soto G, Kumar M, MacDonald ML, Kozorovitskiy Y. Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum. Nat Commun. 2021 Aug 11;12(1):4855. doi: 10.1038/s41467-021-25144-y. PMID: 34381044; PMCID: PMC8357913.
Read The paperKrivinko JM, Erickson SL, MacDonald ML, Garver ME, Sweet RA. Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice. Alzheimers Dement (N Y). 2022 Aug 22;8(1):e12324. doi: 10.1002/trc2.12324. PMID: 36016832; PMCID: PMC9395154.
Read The paperDumrongprechachan V, Salisbury RB, Butler L, MacDonald ML, Kozorovitskiy Y. Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment. Elife. 2022 Oct 14;11:e78847. doi: 10.7554/eLife.78847. PMID: 36239373; PMCID: PMC9629834.
Read The paperMacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA. Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia. JAMA Psychiatry. 2019 Oct 23:1-10. PMID: 31642882.
Read The paperNucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris A, Orsburn B, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga C, Sweet RA, Ross CA, Sawa A, Nucifora FC. Increased protein insolubility in brains from a subset of patients with schizophrenia. American Journal of Psychiatry. 2019 Sep 1;176(9):730-743. PubMed PMID: 31055969.
Read The paperMcKinney BC, MacDonald ML, Newman JT, Shelton MA, DeGiosio RA, Kelly RM, Fish KN, Sampson AR, Lewis DA, Sweet RA. Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 2019 May;44(6):1055-1061. doi: 10.1038/s41386-019-0350-7. 2019 May 44(6):1055-1061. PMID: 30795003.
Read The paperTorregrossa MM, MacDonald ML, Stone KL, Lam TT, Nairn AC, Taylor JR. Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens. Psychopharmacology (Berl). 2019 Jan 236(1):531-543. PMID: 30411139.
Read The paperMacDonald ML, Favo D, Garver M, Sun Z, Arion A, Ding Y, Yates N, Sweet RA, Lewis DA. Laser Capture Microdissection – Targeted Mass Spectrometry: A Method for Multiplexed Protein Quantification Within Individual Layers of The Cerebral Cortex. Neuropsychopharmacology. 2019 Mar 44(4):743-748. PMID: 30390066.
Read The paperH.Y. Wang, M.L. MacDonald, K.E. Borgmann-Winter, A. Banerjee, P. Sleiman, A. Tom, A. Khan, K.C. Lee, P. Roussos, S.J. Siegel, S.E. Hemby, W.B. Bilker, R.E. Gur, C.G. Hahn. mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia. Mol Psychiatry. 2020 Apr;25(4):750-760. PMID: 30214040.
Read The paperRajarajan P , Borrman T, Liao W , Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca E, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind D, Ho SM, MacDonald ML, Hoffman GE, Roussos P, Zhang B, Hahn CG , Weng Z, Brennand KJ, Akbarian S. Neuron-specific Signatures in the Chromosomal Connectome Associated with Schizophrenia Risk. Science. 2018 Dec 14;362(6420). PMID: 30545851.
Read The paperJ.M. Krivinko, S.L. Erickson, Y. Ding, Z. Sun, P. Penzes, M.L. MacDonald, N.A. Yates, M.D. Ikonomovic, O.L. Lopez, R.A. Sweet, J. Kofler. Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease. Am J Psychiatry. 2018 Oct 1;175(10):999-1009. PMID: 30021459.
Read The paperMacDonald ML, Alhassa J, Newman JT, Richard M, Hong Gu H, Ryan M. Kelly RM, Alan R, Sampson AR, Kenneth N. Fish KN, Peter Penzes P, Zachary P. Wills ZP, David A. Lewis DA, Robert A. Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. American Journal of Psychiatry. Jun 1;174(6):586-594. PMID: 28359200.
Read The paperSweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez OL, Fitz NF, Koldamova R, Yates NA. APOE*4 genotype is associated with altered levels of glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to moderate Alzheimer disease. Mol Cell Proteomics. 2016 Jul 15(7):2252-62. PMID: 27103636.
Read The paperKirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun M, Kofler JK, Lopez OL, Yates NA, Sweet RA. Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 2016 Jan 14 75(2):175-82. PMID: 26769253.
Read The paperWang T, Zhao R, Zhou Fang, Ding Y, MacDonald ML, Sweet R, Chen W#. Fast GGM: An efficient algorithm for the inference of Gaussian graphical model. Plos Computational Biology. 2016 Feb 12(2): e1004755. PMID: 26872036.
Read The paperShelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, Moyer CE, DiBitetto JV, Dorph-Petersen KA, Penzes P, Lewis DA, Sweet RA. Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia. Biol Psychiatry. 2015 Sept 78:374-385. PMID: 25818630.
Read The paperMacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015 Jun 77:959-968. PMID: 25433904.
Read The paperD'Aiuto L, Zhi Y, Kumar Das D, Wilcox MR, Johnson JW, McClain L, MacDonald ML, Di Maio R, Schurdak ME, Piazza P, Viggiano L, Sweet R, Kinchington PR, Bhattacharjee AG, Yolken R, Nimgaonkar VL. Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation. Organogenesis. 2014; 10:365-377. PMID: 25629202.
Read The paperBanerjee A, Wang HY, Borgmann-Winter K, Stucky A, Kvasic J, MacDonald ML, Talbot K, Hemby S, Siegel S, Egbujo D, Arnold SE, Sleiman P, Chang X, Hakonarson H, Gur R, Hahn CG. Src kinase hypoactivity as an underlying mechanism for postreceptor NMDA receptor hypofunction in schizophrenia. Molecular Psychiatry. 2014 Oct 21 20(9):1091-100. PMID: 25330739.
Read The paperMacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain Tissue. Mol Cell Proteomics. 2012 Dec 11(12):1670-81. PMID: 22942359.
Read The paperHahn CG, Banerjee A*, MacDonald ML*, Cho DS, Kamins J, Nie J, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA. The Post-Synaptic Density of Human Postmortem Brain Tissues: An Experimental Study Paradigm for Neuropsychiatric Illnesses. PLoS One. 2009 Apr 4(4):e5251. PMID: 19370153.
Read The paperChartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, and Carlezon, WA. Jr. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. 2009 Mar;75(3):704-12. Mol Pharmacol. 2009 Mar;75(3):704-12. PMID: 19106229.
Read The paperBorgmann-Winter KE, Rawson NE, Wang HW, Wang H, MacDonald ML, Ozdener MH, Yee KY, Gomez G, Xu J, Bryant B, Adamek G, Mirza N, Pribitkin E, Hahn CG. Human olfactory epithelial cells generated in vitro differentiate to express a diversity of neuronal functions. Neuroscience. 2009 Jan 23;158(2):642-53. PMID: 18996445.
Read The paperMacDonald ML, Murray IVJ, Axelsen PH. Mass spectrometric analysis demonstrates that BODIPY 581/591 C11 overestimates and inhibits oxidative lipid damage. Free Radicals in Biology and Medicine. 2007 May 1;42(9):1392-7. PMID: 17395012.
Read The paperLevine JB, Youngs RM, MacDonald ML, Chu M, Leeder AD, Konradi C. Isolation Rearing and Hyperlocomotion are Associated with Reduced Immediate Early Gene Expression Levels in the Medial Prefrontal Cortex. Neuroscience. 2007 Mar 2;145(1):42-55. PMID: 17239545.
Read The paperNaydenov AV*, MacDonald ML*. Onger D, Konradi C. Differences in lymphocyte electron transport gene expression levels between bipolar subjects and normal controls in response to glucose deprivation stress. Archives of General Psychiatry. 2007 May 64(5):555-64. PMID: 17485607.
Read The paperMacDonald ML, Naydenov A, Matzilevich D, Konradi C. Decrease in Creatine Kinase Messenger RNA Expression in the Hippocampus and Dorsolateral Prefrontal Cortex in Bipolar Disorder. Bipolar Disorder. 2006 June 8(3):255-64. PMID: 16696827.
Read The paperMacDonald ML, Eaton M, Dudman T, Konradi K. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biological Psychiatry. 2005 May 1;57(9):1041-51. PMID: 15860345.
Read The paperMeng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDonald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA. Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases. J Med Chem. 2004 Dec 2;47(25):6420-32. PMID: 15566311.
Read The paperKonradi C, Eaton M, MacDonald ML, Walsh J, Benes F, Heckers S. Molecular Evidence for Mitochondrial Dysfunction in Bipolar Disorder. Archives of General Psychiatry. 2004 March 61(3) 300-308. PMID: 14993118.
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